|
KMID : 0379520030190030227
|
|
한국독성학회지
2003 Volume.19 No. 3 p.227 ~ p.234
|
|
|
Assessment of Embryotoxicity of 2-Bromopropane in ICR Mice
|
|
Kim Jong-Choon
Shin Dong-Ho
Kim Seong-Ho
Oh Ki-Seok
Kim Hyeon-Yeong
Heo Jeong-Doo
Jiang Cheng-Zhe
Chung Moon-Koo
|
|
|
Abstract
|
|
|
|
2-Bromopropane (2-BP), a halogenated propane analogue, is a substitute for chlorofluorocarbones (CFCs) which have a great potential to destroy the ozone layer and to warm the earth’s environment. The present study was undertaken to evaluate the potential adverse effects of 2-BP on pregnant dams and embryo-fetal development after maternal exposure during the gestational days (GD) 6 through 17 in ICR mice. The test chemical was administered subcutaneously to pregnant mice at dose levels of 0, 313, 625 or 1,250 mg/kg/day. All dams were subjected to caesarean section on GD 18 and their fetuses were examined for external, visceral and skeletal abnormalities. In the 1,250 mg/kg group, maternal toxicity included an increase in the incidence of abnormal clinical signs and a decrease in the maternal body weight, body weight gain, and corrected body weight. Developmental toxicity included a decrease in the fetal body weight, a reduction in the placental weight, an increase in the fetal skeletal variation and ossification delay. There were no adverse effects on either pregnant dams or embryo-fetal development in the 313 and 625 mg/kg groups. These results suggest that a 12-day subcutaneous dose of 2-BP is embryotoxic at a maternally toxic dose (i.e., 1,250 mg/kg/day) in ICR mice. In the present experimental condition, the no-observed-adverse-effect level of 2-BP is considered to be 625 mg/kg/day for dams and embryo-fetuses, respectively.
|
|
|
KEYWORD
|
|
|
2-Bromopropane, Maternal toxicity, Developmental toxicity, Teratogenicity, Pregnant mice.
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|
|